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Research has demonstrated that roasting can reduce histamine levels in coffee by approximately 3050% compared to green bean baseline, with darker roasts showing greater reduction than lighter roasts due to extended heat exposure [ 2 ]

Comparisons are difficult at this stage, with the studies having different populations and durations, but UBT251s data is certainly notable

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Although TNF at this dose exerted no cytotoxic effects, H 2 O 2 pretreatment resulted in marked cell death in both HepG2 cells and NCTC1469 cells in response to TNF challenge (Fig