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Crit Rev Clin Lab Sci (2008) 45:123

Pro-inflammatory cytokines reduce the production of BH4, thus potentially reducing dopamine levels in situations of systemic inflammation.[ref] One study explains: Dopaminergic neurotransmission is very sensitive to inflammation

A recent, 2-week, open-label pilot-study in 16 PD patients showed reduced plasma level variability compared to oral IR LD/CD and that DopaFuse treatment over 11 days was associated with matching OFF-time reduction and ON-time gain of 1.7 h [24]

For analysis, ratiometric images of the whole FOV were generated with the method described before

10.1042/bj0150286 Biochem J

TB-500 (Thymosin Beta-4 Fragment) is derived from the naturally occurring protein Thymosin Beta-4, which plays a critical role in actin sequestration and cell motility