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Free Radic Biol Med 47:S111

Gallbladder and biliary disease: GLP-1based therapies have been associated with an increased risk of gallbladder problems, including gallstones and cholecystitis

METHODS: For a 21-day period, rats were treated intraperitoneally with either hydroxocobalamin (70 mg kg-1 per day, n = 14), cobalt chloride hexahydrate (12 mg kg-1 per day, n = 14) or saline (n = 10)

Image source: nature.com

This steady increase shows that more individuals are coming forward after experiencing serious side effects linked to GLP-1 drugs like Ozempic, Mounjaro, and Wegovy

Co-IP experiment T24 cells expressing Flag and 13myc tagged proteins, as well as PGC-1::Flag and NXF1::13myc fusion proteins, were collected