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RTV and lopinavir (LPV), two frequently prescribed PIs, can increase ROS production in human arterial endothelial cells (Lefvre et al., 2010) and are known to induce ROS through a perturbed mitochondrial function in cardiomyocytes ( Indinavir (IDV) and nelfinavir (NFV) have been shown to elicit ROS production in skin fibroblast cultures in vitro and in patients adipose tissue in vivo (Viengchareun et al., 2007)

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