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Monosodium urate crystals have a specific ability to stimulate DCs maturation and promote the priming of T cells via TLR2/4 compared with other crystals like allopurinol crystals and basic calcium phosphate

228,229,230 Inhibiting xCT The search for strategies and drugs aimed at inducing oxidative stress has revealed xCT to be a suitable targetincreased glutamate efflux through this antiporter is an important process for cells to generate sufficient glutathione to cope with high intracellular ROS levels

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Glucose metabolism substrates and metabolites are among the best characterized biomarkers in these studies

doi: 10.7554/eLife.85009