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Some drugs (including colchicine and metformin), as well as vitamins like vitamin C and folic acid, can reduce the levels of vitamin B12 in your body or affect the absorption of it

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Whether you recently changed your diet, supplements, or hydration habits

That may be less common now that there are so many other options, including Wegovy and Zepbound , which are specifically for weight loss, rather than primarily for type 2 diabetes

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This process also contributes to the removal of damaged organelles, such as mitochondria and ER, and misfolded or aggregate-prone proteins (Mizushima, 2011)