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6I) revealed that YTHDF1 knockdown significantly down-regulated cytochrome C, while up-regulating Ferritin, TFAM, and GPX4, while SLC7A5 overexpression reversed the expression pattern of these proteins

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Mechanistically, this explains the disconnect between comet assay readouts and biological outcomes: BCDOX-Lipo reduces acute DNA damage frequency (lower tailed % than DOX-Lipo) yet strengthens cell death pathways

Wang Y, Chen WJ, Han YY, Xu X, Yang AX, Wei J, Hong DJ, Fang X, Chen TT (2023) Neuroprotective effect of engineered Clostridiumbutyricum-pMTL007-GLP-1 on Parkinsons disease mice models via promoting mitophagy

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Numerical endpoints that were intractably non-normal were assessed by the Mann-Whitney U test