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Similarly, Retatrutide induced a dose-dependent reduction in body weight

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Marcus SN, Heaton KW (1986) Intestinal transit, deoxycholic acid and the cholesterol saturation of bilethree inter-related factors

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This must be carefully evaluated to avoid side effects at these higher doses, so your medical provider will weigh the risk/benefit of these doses based on your weight loss and side effects with the lower dosages