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Bupropion is an atypical antidepressant that affects dopamine and norepinephrine, but not in the way traditional stimulants do
2 Glycemic control also improved, with A1C reductions of up to an average of 1.6 percentage points across the active arms versus 0.2 percentage points for placebo, from a baseline A1C of 7.7%
No impact on bone fractures : If osteoporosis is a concern, the GLP-1 receptor agonists were shown not to increase fracture rates.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Works best with Exercise: A randomized clinical trial found that GLP-1 RAs work best for weight loss when combined with exercise
Like other modern incretin-family research peptides, GLP-3RT is studied at the protein and receptor level, not in dietary supplement contexts