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ATG12 is a crucial protein in autophagy, involved in the formation of autophagosomes, a double-membrane vesicle that captures and delivers cellular components to lysosomes for degradation [70, 71]

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p53 inhibits the transcription of SLC7A11 by directly binding to its promoter in fibroblasts and certain cancer cells, which then affects the GPX4-regulated classical pathway and ultimately leads to ferroptosis (Fig

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The Journal of Clinical Endocrinology & Metabolism, 86(4), 1464-1469