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Warning signs include yellowing of the skin or eyes, dark urine, nausea, vomiting, unusual tiredness, weakness, stomach or abdominal pain, or loss of appetite

Exp Ther Med 2017, 14(5): 5219-5227

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Axonal integrity predicts cortical reorganisation following cervical injury

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demonstrated that the IGF-1/IGF-1R axis induces phosphorylation of ERa through ribosomal S6 kinase 1 (S6K1), a downstream molecule of the PI3K/AKT/mTOR pathway