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This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients

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10.1016/j.ijpharm.2022.121461PubMed Abstract | CrossRef Full Text | Google Scholar 24 CallegariE.KalgutkarA

GLP-1 receptor agonists like semaglutide and liraglutide have transformed type 2 diabetes and weight management, but questions persist about their effects on skeletal health

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