However, further human studies are necessary to evaluate the feasibility and efficacy of this approach (Mamic et al., 2021)
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In those cases, sterile water (preservative-free) must be used, and if multiple doses are needed, other strategies (like preparing fresh solutions more frequently) are employed rather than relying on bacteriostatic water
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Although these values indicate potential limitations in detecting true associations, they do not undermine the overall robustness of our analysis