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Covariate balance was considered satisfactory when the standardized mean difference (SMD) was less than 0.1 ( The selection of baseline covariates was informed by prior literature and clinical relevance, with the aim of capturing key demographic characteristics, comorbid conditions, and laboratory parameters that are known or plausibly associated with both treatment allocation and the risk of venous thromboembolism

Gupta NA, Mells J, Dunham RM, Grakoui A, Handy J, Saxena NK, Anania FA

Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

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The key is treating medication discontinuation as a transition point, not an endpoint