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doi: 10.1016/j.phrs.2024.107250 169 ChenXShiCHeMXiongSXiaX
Eli Lilly submitted the orforglipron NDA to the FDA in Q1 2026 following ATTAIN Phase 3 trial data showing 14.7% body weight reduction at 45mg positioning the worlds first oral small molecule GLP-1 receptor agonist for obesity for anticipated FDA approval in late 2026 or 2027
Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies
Seventeen members (63 percent of respondents) said their GLP-1 medication helped or reduced their HS symptoms
One driver of regulatory T cell response in the lymphoid follicle may be the API in the peptide drugs
Notably, small pro-inflammatory DAMPs, including IL-1 and IL-18, can directly exit the cell through GSDMD pores [123]
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