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The mechanism of heart rate increase with semaglutide is primarily indirect, mediated through autonomic nervous system effects rather than direct cardiac stimulation

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Cell 161: 215227 HajduCronin YM, Chen WJ, Patikoglou G, Koelle MR, Sternberg PW (1999) Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans : the RGS protein EAT16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity