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However, this weight loss is less pronounced in those with DM2, suggesting that factors like insulin resistance and constant high blood sugar reduce the effectiveness of these drugs

doi: 10.1124/jpet.102.037580

Compelling evidence from landmark clinical trials, particularly STEP-HFpEF, STEP-HFpEF DM and SUMMIT, has established the efficacy of GLP-1RAs in improving HF-related symptoms and quality of life, as well as reducing worsening HF events, in the prevalent phenotype of HFpEF in the setting of obesity and T2D

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Significantly, GLP-1RAs demonstrate favorable protective effects against hepatocellular and prostate cancer