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And this becomes a vicious cycle

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This decline correlates with reduced tissue regeneration capacity.[2][3] Structurally, GHK-Cu features a Cu(II) ion coordinated in a distorted square-planar pyramid by four nitrogen atoms: the amino-N of glycine, the amide-N of the Gly-His peptide bond, the imidazole-N of histidine, and an oxygen from water or a carboxyl group

Ramli et al., 2022

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Researchers commonly examine GHK-Cu in controlled experimental systems involving peptide signaling pathways, copper ion transport behavior, extracellular matrix organization models, and gene expression regulation frameworks