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While no regulatory actions have been taken to restrict the use of these therapies, the American Academy of Ophthalmology has recommended heightened monitoring for patients who experience vision changes while on these medications

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This is thought to be due to the presence of SOD1 in the mitochondrial membrane gap (Ehinger et al., 2015

The median time-to-onset (TTO) was 6.36 days (Interquartile Range (IQR) 0.85 31.2) with the Weibull shape parameter () of 0.44, indicating an early failure profile

Navarro, S

Most individuals report noticeable appetite suppression within the first two weeks of treatment, though maximum benefits typically emerge over 8-12 weeks as the body adapts to the medication