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Modern GLP-1 medicines such as semaglutide and tirzepatide frequently result in more than 10% weight loss in people living with obesity, while maintaining a favorable safety profile

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found that active GSH metabolism within tumors further suppresses immune responses, such as IFN- signaling and PD-1/PD-L1 interactions, while reducing the number of M1 macrophages and increasing the proportion of M2 macrophages

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