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For estimation of the importance of glucagon receptors, we used mice with global knockout of Gcgr ( Gcgr / ) [22], and regarding the GLP-1 receptor we used the GLP-1 receptor antagonist exendin 9-39 (Ex9)

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GLP-1 drugs are a class of medications that mimic the action of the naturally occurring hormone glucagon-like peptide-1 (GLP-1)

However, their long life-span, penetration through the bloodbrain barrier (BBB) 13 , and high therapeutic doses may allow them to directly act on central nervous system GLP-1Rs 12 , thereby causing CNS-dependent side effects

Clinical trials showed average weight loss of 15%17%, roughly double that of previous drugs