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AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity

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This hypothesis is further supported by clinical observations that more than 60% of accumulated fatty acids in the liver are derived from the circulation in NAFLD patients 7,8

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In addition to its participation in the WWC, ascorbate is also required for the regeneration of lipid-soluble antioxidants, particularly tocopherols and tocotrienols (vitamin E), which protect the polyunsaturated fatty acids in the thylakoid membranes from oxidation to chromanoxyl radicals by singlet oxygen