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Many heavy drinkers miss out on having a balanced diet rich in vitamin B12

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These individual unimolecular multi-agonists activities seemed to harmonize the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity

Its considered essential only because the human body relies primarily on diet as its main source