For example, in the SURMOUNT-4 trial, tirzepatide discontinuers were randomized to a placebo, and they were unaware whether they were receiving tirzepatide or not. In real-world settings, the most common reasons for discontinuation are cost or insurance-related issues, and side effects, with the former predominating, he added
Inject the Medication: Insert the needle into your skin at a 90-degree angle
For people with type 2 diabetes, the medications may also improve blood sugar control
Your product recommendation Compounded GLP-1/GIP Get started for as little as $149 a month* $299/mo thereafter With your personalized calorie plan, protein goal, and your prescribed GLP-1 support, you have a blueprint to help you start achieving your weight loss goals
Some people who take GLP-1s seem to develop an increase in heart rate by about 5-20 beats per minute, but there is no evidence that this is harmful Long-term risks Thyroid cancer
Weight-related comorbidities that lower the BMI threshold If your BMI is 27.0-29.9, you qualify for Mounjaro if you have at least one of these conditions: Cardiovascular and metabolic: Hypertension (blood pressure 130/80 mmHg or higher, or on antihypertensive medication) Dyslipidemia (LDL 130 mg/dL or higher, triglycerides 150 mg/dL or higher, or on statin therapy) Type 2 diabetes (this moves you to the diabetes pathway, which has no BMI minimum) Prediabetes (A1C 5.7%-6.4% or fasting glucose 100-125 mg/dL) Coronary artery disease History of stroke or transient ischemic attack Respiratory: Obstructive sleep apnea (diagnosed by sleep study, not just symptoms) Obesity hypoventilation syndrome Musculoskeletal: Osteoarthritis with documented functional impairment Chronic lower back pain attributable to excess weight Metabolic: Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) Polycystic ovary syndrome (PCOS) Reproductive: Infertility related to anovulation and obesity The comorbidity must be documented in your medical record
