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[109] proved that IN delivery of desmopressin peptide to the brain tissue was more efficient as a nasal powder, showing superior bioavailability than commercial nasal liquid spray and sublingual tablet

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doi:10.1212/CPJ.0000000000000043 In addition, there are several limitations in the research that has been conducted, such as: Many studies do not include the use of fluoroscopy or x-ray to verify the proper placement of the medication despite the fact that fluoroscopic guidance is routinely used today

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Most peptide protocols fall outside standard dental or medical insurance coverage, as many are prescribed off-label or as compounded preparations