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Your body actually produces it within your own cells, primarily in the liver

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[Abstract]2020 Oct 16;15(10):2722-2730

Differential modulation of AMPK/PPAR/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains

Notably, PPAR alone is not sufficient to restore redox homeostasis and promote the M2 phenotype, as demonstrated by the exacerbation of neuroinflammatory cytokine production in NRF2-deficient mice challenged with LPS (Innamorato et al., 2008)

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