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doi:10.3205/000247

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In the single-dose part of the study, adverse events (AEs) occurring in 20% of subjects in any of the combination groups that did not occur in the placebo group were muscle spasms, mouth ulcerations/aphthous ulcers, and urinary tract infection (Table 4)

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These approaches include either targeting all -coronaviruses, targeting a subset of these viruses (such as sarbecoviruses), or even targeting a single species with the aim of developing a pan-variant or variant-proof vaccine for SARS-CoV-2 (Table 1)