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Together, these finding indicate that the toxic effects of DOX on the heart are strongly associated with iron overload and ferroptosis in mitochondria, indicating that targeting ferroptosis could serve as a promising therapeutic strategy for protecting the hearts of cancer patients from DOX-induced cardiomyopathy

However, the limited follow-up duration of 6 months raised concerns about potential reverse causality, as undetected suicidal ideation and medical conditions might have influenced the choice of particular anti-obesity or anti-diabetic drugs

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Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship