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[7] Causes of upper gastrointestinal bleeding that may result in melena include malignant tumors affecting the esophagus, stomach or small intestine, hemorrhagic blood diseases, such as thrombocytopenia and hemophilia, gastritis, stomach cancer, esophageal varices, Meckel's diverticulum and Mallory-Weiss syndrome

This is critical data to have before seeking FDA approval

Constipation Regular bowel movements are essential when taking semaglutide

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What about zero-calorie sweeteners