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More serious but rare risks include pancreatitis, gallbladder problems, and the theoretical thyroid cancer risk seen in rodent studies (not confirmed in humans at therapeutic doses, but it is why the thyroid cancer history exclusion exists)

Finally, for diseases with conflicting data like AMD, a risk-benefit assessment framework is needed

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Most BCCs are local invasive and rarely metastasize (35)

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doi: 10.1038/ismej.2017.24 146 HamerHMJonkersDVenemaKVanhoutvinSTroostFJBrummerRJ