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Acknowledgements Author gratefully acknowledges Dr.S.G.Bhat, Head, Department of Biochemistry and Nutrition and Dr.V.Prakash, Director, CFTRI, Mysore for their encouragement in preparing this review

KPV (LysProVal) A minimal anti-inflammatory tripeptide fragment of -melanocyte-stimulating hormone (-MSH), KPV acts primarily through MC1R-mediated and NF-Binhibitory pathways

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Unfortunately, it is known that the astrocytic protection afforded to neurons is limited, possibly due to a decline in GSH trafficking by chronic iNOS induction [52]

In animal models it also reduced brain inflammation and improved behavior

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