Target peptide quantification : allows construction of a direct cerebral pharmacokinetic curve, compared to plasma to calculate the brain/plasma ratio
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Zhong W, Gu B, Gu Y, Groome LJ, Sun J, Wang Y
This study included 78 patients who received 10 mcg of subcutaneous lixisenatide once daily for 14 days, followed by 20 mcg once daily for the remainder of the 12-month period, and 78 patients who received placebo
Common gastrointestinal effects of Wegovy include (according to the UK SmPC): Nausea (reported in up to 44% of patients) Diarrhoea (approximately 30% of patients) Vomiting (24% of patients) Constipation (24% of patients) Abdominal pain and bloating Many antibiotics, particularly broad-spectrum agents , can disrupt the normal gut microbiome, leading to diarrhoea, abdominal discomfort, nausea, and occasionally more serious complications such as Clostridioides difficile infection
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