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Take 1 Tbsp (15 mL) preferably on an empty stomach, before meals, or before exercise

6.6 Effects on renal functions The result of clinical trials of tirzepatide on kidney function indicates potential renal advantages, especially in individuals with type-2 diabetes (T2D) and a heightened cardiovascular risk.In the SURPASS-4 (NCT03730662) trial, tirzepatide was observed to reduce occurrence of the composite kidney endpoint (like eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new-onset macro albuminuria) in comparison to those receiving insulin glargine

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Surgery is often performed with techniques such as liposuction, which can help reduce the abnormal fat accumulation in the affected areas