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Supplementation to avoid ariboflavinosis is often unnecessary as enough riboflavin is obtainable from a well-balanced diet, unless the diet is severely restricted or there are underlying health conditions [46]

Once a vial has been pierced, mark the date of first puncture and discard 28 days later in line with standard multiple-dose vial practice, and never use beyond the printed expiry even if the 28 days have not elapsed

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