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Qsymia (phentermine-topiramate) comes in 3.75/23 mg, 7.5/46 mg, 11.25/69 mg, or 15/92 mg extended-release oral capsules, taken once daily

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SURMOUNT-3 and SURMOUNT-4 Trials (2023) In a 2023 NEJM publication , researchers reported that Retatrutide: Produced an average of 24.2% total body weight loss at 48 weeks in individuals without diabetes Patients on the highest dose lost over 58 pounds on average Outperformed all currently available GLP-1 and GIP analogs Additional findings included: Significant reduction in liver fat (up to 85%) Improved insulin sensitivity and HOMA-IR scores Reduced blood pressure, triglycerides, and inflammation markers These results are unmatched in obesity pharmacotherapy history and suggest that Retatrutide could soon set a new gold standard for metabolic treatment

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However, an early deterioration in retinopathy, such as with soft exudates, microaneurysms and haemorrhage, can occur in the first six months after rapid correction of significant hyperglycaemia