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By May 1921 Banting and Best had sufficient quantities of insulin to begin testing it in dogs with well-established diabetes

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Diabetologia 65(Suppl 1):S290S291 Gastaldelli A, Cusi K, Fernandez Lando L, Bray R, Brouwers B, Rodriguez A (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

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Exenatide is 53% identical to GLP-1 at the level of amino acids and binds to and activates the GLP-1R

This compares very favourably to about a 20% absorption rate of intravenous vitamin C into cells