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For women with vitamin B12 below 358.7 pg/mL, we infer supplementation could improve pregnancy outcomes by restoring homocysteine homeostasis and enhancing oocyte quality, consistent with randomized trials showing that combined B12 and folate supplementation reduces oxidative stress and supports embryo development [7, 8]

Hypermethylation or hypomethylation of DNA in specific regions leads to abnormal repression or activation of genes, thereby promoting the aging process

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