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GCL belongs to the class of proteins that are sensitive to oxidative stress, and its expression is mainly under the regulation of the Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), a transcription factor that regulates a wide array of antioxidant responsive element-driven genes in various cell types (Baldelli et al., 2013)

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Specifically, in pancreatic and breast cancer models, macrophages and fibroblasts were shown to be the main producers of IGF1, supporting drug resistance and metastasis of cancer cells [39, 40]

Rituximab depletes CD20-positive B cells

[DOI] [PubMed] [Google Scholar] 15.Jones A.L., Jarvie D.R., Simpson D., Hayes P.C., Prescott L.F