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By June 2021, synthetic opioids were involved in an estimated 87% of opioid deaths and 65% of all drug overdose deaths.(5) This has made opioid overdose a leading cause of death in the United States.(6) Figures 1 and 2: NIDA, Drug Overdose Deaths: Facts and Figures, Fentanyl Fentanyl is 50 times more potent than heroin and 100 times more potent than morphine

Rodent studies using metal oxide and silver nanoparticles have shown that high experimental doses of such materials can induce oxidative stress and inflammatory responses in the liver and gut, although these doses far exceed typical human dietary exposures (203207)

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