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The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

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Muscle preservation: Most weight lost was body fat rather than lean tissue, though some muscle loss is expected with any significant weight reduction

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Performed the experiments: MM AZ CC JA

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