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These purified HBs demonstrated robust self-renewal capacity, expanding in a small-molecule-defined medium (ACDFSV) for over 20 passages without losing their proliferative capacity or characteristic morphology

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Actually, let me reframe that

Zhang X, Tang B, Guo J

10.1186/s13048-024-01434-z 26 ChenW.QiukaiE.SunB.ZhangP.LiN.FeiS.et al (2023a)

3.6.4 Interventions 3.6.4.1 Probiotics Gut dysbiosis has been increasingly recognized as a contributor to cardiovascular disease (CVD) pathogenesis through mechanisms involving systemic inflammation and metabolic disruption, with probiotics and prebiotics emerging as promising strategies to restore microbiota balance and improve cardiovascular markers such as LDL cholesterol and high-sensitivity C-reactive protein (hs-CRP