The area postrema, which lacks a blood-brain barrier, detects circulating signals and can trigger nausea
Effects typically become noticeable within 1-2 weeks at the 4mg level
This is written for people with type 2 diabetes (and those with prediabetes or insulin resistance) who want to understand their treatment options properly without hype or confusion
Their A1C levels also dropped by an average of 1.3 to 1.6 percent, depending on dosage
Many people have more than one of these problems, and weight loss from GLP-1s can make them all betterno other medications can do that. On top of that, some research also shows positive effects on reducing alcohol intake, mood, and more in some individuals
The explanation for the discrepancy in the reduction of MACE in patients treated with SGLT2i in DECLARE-TIMI 58 suggests that the benefits of SGLT2i may be more pronounced in patients with a higher risk of cardiovascular disease