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The leptin-melanocortin axis, the opioid system, glucagon-like peptide-1 (GLP-1)/glucagon-like peptide-1 receptor (GLP-1R) system, and fibroblast growth factor 21 (FGF21)/its receptor complex FGFR1c/-klotho axis are several common pathways confirmed by researches and pharmacological targets that play an essential role in regulating energy balance and feeding behavior (2)

doi: 10.1016/j.bbadis.2018.05.012 127 BruenRCurleySKajaniSCreanDOReillyMELucittMBet al

Tirzepatide also reduces liver fat, and SURMOUNT trial substudies have shown meaningful improvements in hepatic steatosis

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Staying hydrated can keep digestion running smoothly and help with other symptoms like bloating and heartburn