Semaglutide remains stable at room temperature (up to 86F) for 28 days after opening, and airplane cabins typically maintain 7075F, which is safe
Journal of Pharmaceutical Sciences, 107(5), 1396-1404
For this reason, guidelines are widely accepted limiting the amount of fat removed at one setting to no more than 5 liters
doi:10.1111/1753-0407.12616 24
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GLP1 drugs target this process at the source