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The cardiovascular actions of GLP-1 have garnered increasing attention as GLP-1R agonists are used to treat human subjects with diabetes and obesity that may be at increased risk for development of heart disease

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others (like a tri-agonist by Pfizer) are in mid-stage trials

255 Hcy can increase damage in the hippocampus of ischemic-hypoxic models in rats, which is consistent with the heightened susceptibility of patients with hyperhomocysteinemia to ischemic events

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