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Compared to H1271K, the T1273A mutant showed more post-ER staining in the perinuclear region, and this colocalised with the cis-Golgi marker GM130, consistent with a protein that is leaving the ER but then being recycled by binding COPI (Supplementary Fig

A 2025 narrative review in Current Reviews in Musculoskeletal Medicine identified only three published human studies: Lee & Padgett (2021) on knee pain (n=16), Lee et al

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It works by inhibiting the NNMT enzymea known contributor to fat storage and metabolic slowdown