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Three specific conditions qualify for Tier 2 (BMI 30 or higher): (1) heart failure with preserved ejection fraction (HFpEF), (2) uncontrolled hypertension despite treatment with two or more antihypertensive medications (systolic over 140 or diastolic over 90), and (3) chronic kidney disease stage 3a or higher (estimated GFR below 60)

References Dungan, Kathleen, and Anthony DeSantis

doi: 10.1172/JCI990

It can manifest as nosebleeds, heavier-than-normal periods, prolonged bleeding after a minor cut or bleeding gums

Potential Gastrointestinal Changes: This is where many of the initial side effects can manifest

Frequency and amount of treatments is dependent upon a series of health factors