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The extended-release (ER) formulation encapsulates exenatide within biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres, which form a polymeric matrix that allows sustained drug release following SC administration [13, 14, 58]

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This does not mean subcutaneous is ineffective, but it means you cannot simply transpose a nanomole-per-kilogram IV number to a subcutaneous protocol and expect equivalent CNS exposure

4.2 LBDDSs for gout and hyperuricemia LBDDSs represent a class of platforms utilizing lipid materials to enhance drug bioavailability, stability, and targeting efficiency (Savla et al., 2017)

Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M, et al