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While GHK-CU generally promotes healthy collagen remodeling, excessive MMP-1 activity can fragment healthy collagen before new collagen fully develops

The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot

Collagen Production and Tissue Regeneration It increases fibroblast activity, the cells responsible for producing collagen and repairing connective tissues such as tendons and ligaments

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