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Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer

Methylsulfonylmethane inhibits cortisol-induced stress through p53-mediated SDHA/HPRT1 expression in racehorse skeletal muscle cells: A primary step against exercise stress

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Over time, the distribution of disease can extend or regress

Thats exactly what makes it useful for healing, but it also means it could theoretically stimulate tumor growth in a dog with existing cancer